B-COMPLEX FORMULA

Cellular metabolism depends onthe accessibility of B-complexvitamins. Each of the vitaminsin the B-Complex groupis either a coenzyme for important metabolic processes, or is a precursor needed for the formation of a certain coenzyme.

B1 (Thiamin), is the necessary coenzyme needed both for the metabolism of carbohydrates and for the production of acetylcholine.

B2 (Riboflavin),after having turned into its bioactive form (riboflavin 5-phosphate) so as to be able to be used by the body,is a precursor for the formation of coenzymes.Vitamin B2 in the form of riboflavin 5-phosphate is a constituentof the prosthetic groups (FAD and FMN). These areflavoproteinswho take part in oxidation -reduction reactionsat numerous metabolic pathways, as well as in energy production through the respiratory chain.

B3 (Niacin), is a precursor for the formation of coenzymes and plays an important role in energy transfer reactions for the metabolism of sugars, fats and alcohol.

B5 (Pantothenic acid) is a precursor for the production of Coenzyme-A (CoA)which is needed for the metabolism of a plethora of molecules e.g.amino acids, fatty acids, phospholipids etc.

B6 (Pyridoxine) in the form of pyridoxal 5 – phosphate is an important coenzyme for decarboxylation (deamination of aminoacids e.g. of 5-hydroxy-tryptophan into serotonin, is a coenzyme in transamination reactions where the body is supplied by non-essential amino acids.

B9 (Folic acid) interacts with Vitamin B12 for DNA synthesis that is a necessary component for all the cells in the body.

B12 (Cobalamin) which is its active form, is the necessary coenzyme for the processing of carbohydrates, proteins and fats and participates in the formation of red blood cells. It is also required for the maintenance of the nerve sheaths.

B8 (Inositol) is an important intermediate key element of the body’s second messengers andalso the dominant component of phospholipids found in cell membraneswhich is involved in many biological processes.

All the components of groupB vitamins interact with one another and one key feature of Doctors Formulas Vitamin -B Complexis that it contains all the necessary vitamins of the B group. They contribute to the normal functioning of the metabolic process aimed at energy production, they protect cells from oxidative stress and reduce fatigue and tiredness.

Bibliography: 1. National Academy of Sciences. 2. Institute of Medicine. Food and Nutrition Board, ed. (1998). «Chapter 8 - Folate». 3. Dietary Reference Intakes for Thiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington, D.C.: National Academy Press. Stipanuk, M.H. (2006). 4. Biochemical, physiological, molecular aspects of human nutrition (2nd ed.). St Louis: Saunders Elsevier p.667 University of Bristol (2002). 5. «Pantothenic Acid». Retrieved 16 September 2012. 6. Hum Psychopharmacol. 2011;26(7):470-6. 7. Eur J Clin Nutr. 2004;58(11):1518-24. 8. Ann Neurol. 2011;69(2):352-9. 9. Curr Concepts Nutr.1983;12:1-12. 10. Ann N Y Acad Sci. 1980;355:80-97. 11. J Nutr. 1999 Apr;129(4):779-82.«Para-aminobenzoic acid».12. Medline Plus Medical Encyclopedia. 12. United States National Institutes of Health. 13. Retrieved 24 January 2014.

Notification number of the National Organization for Medicines (EOF): 50991 / 23-06-2016

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