INOSITOL FORMULA

Inositol Formula is a dietary supplement that contributes to the normal functioning of the nervous system, due to its special composition. Inositol, also known as vitamin B8, is a natural isomer of glucose. It is an important intermediate key element of the body’s second messengers, as well as a main component of phospholipids in the cell membranes involved in many biological processes.

Its unique chemical structure enables it to “enter” and "exit” cells, highlighting its importance in the body. Its role is important in determining how the neurotransmitters operate in the brain and in the body, including the reversal of the desensitization of serotonin, thus regulating serotonin activity.

In addition, it is important in signal transduction for calcium and insulin elements. It is also a component of the biological information exchange system.

Inositol contributes to the information processing procedure inside the cell, e.g. biological information contained in hormones. Second messengers are molecules within the cells that act to transmit signals from a receptor to a specific target.

When these substances were discovered, the term, “second messengers” was coined, so as to distinguish them from the hormones and other molecules that function outside the cell as "first messengers" in the transmission of biological information.

A large number of molecules have been classified as second messengers including molecules derived from phospholipids (inositol triphosphate) among others.

A general mechanism/system of second messengers sequence can be divided into four stages:

(1) the agonist activates a receptor that is bound to the membrane.

(2)The activated G protein produces a basic operator.

(3)The primary effect stimulates the synthesis of the second messenger.

(4)The second messenger activates a certain cellular process.

The receptors associated with the G-protein for the ΡΙΡ2 system (phosphatidylinositol 4,5-bisphosphate) messenger, produces two operators, Phospholipase C (PLC) and Phosphoinositide 3-kinase (Pi3k). PLC as operator produces two different second messengers, inositol triphosphate (IP3) and sn-1,2- diacylglycerol (DAG).

IP3 (inositol triphosphate) is soluble and diffuses freely in the cytoplasm. As a second messenger, it is recognized by the inositol triphosphate receptor (IP3R), a Ca2 + channel in the membrane of the endoplasmic reticulum (ER) which stores intracellular Ca2 +.

The attachment of (inositol triphosphate) IR3 to its receptor releases Ca2 + from the endoplasmic reticulum to the cytoplasm which in normal conditions is poor in Ca2 +, which in turn activates the various cell procedures associated with Ca2 +.

Specifically, in the blood vessels, the increase of Ca2 + concentration from IP3 (inositol triphosphate) releases nitric oxide, which then diffuses into the smooth muscle tissue and causes relaxation. In a paper published in “Nature” in 1984, inositol triphosphate is officially characterized as a second messenger in the transfer of cell signals.

By 2010, the volume of bibliographies in many scientific publications journals referring to IP3 exceeded 20,000 references. Its role begins in the field of biology, is involved in medicine (in specialties such as Neurology, Endocrinology, and Pathology), and is realized in the pharmaceutical industry.

The role of inositol in the nervous system has also proven to be vital.

Notification number of the National Organization for Medicines (EOF): 16897 / 15-02-2016.

The notification number in the National Organization for Medicines (EOF) does not serve as an authorization for marketing by the EOF.