Evaluation of Liposomal Vitamin B12 supplementation
Liposomal Technology ensures high Vitamin B12 absorption
Evaluation of Liposomal Vitamin B12 supplementation
Vitamin B12 deficiency is a very common problem among people of all ages and ethnicities that may cause some serious health problems if left untreated. Traditionally intramuscular injection of B12 was the most common way of treatment, although in recent years a lot of studies have shown that oral supplementation is also effective.
Liposomal vitamin B12 has ideal physicochemical characteristics (i.e. size around 450nm and positive surface charge).
Namely, we evaluated how does liposomal supplementation affect B12 levels in participants of this study. For this reason, we organized a case series study. The aim of this investigation is to measure the effect of liposomal B12 supplementation in the bloodstream and to evaluate the reproducibility of this effect regardless of lifestyle choices, medication and basic biometric differences between people taking the supplement. We contacted a case series study in a sample of 53 people above 50 years old with a baseline of B12 below 225μg/ml and we measured their B12 levels 1 week after the treatment start, 1 month after treatment and 2 months after treatment with liposomal B12 supplement sublingually administered 3 times per day providing a total of 1000μg of methylcobalamin daily.
Liposomal B12 supplementation was found effective in a very short period of time, which is very beneficial for patients.
Vitamin B12 levels have been significantly increased by a median of 54.68% in the first week of treatment, 105.51% in the first month and 270% after two months of treatment. B12 levels increase was found not to be relevant to demographic, biometric, medical treatment and lifestyle factors. Further studies may also be useful to evaluate whether liposomal B12 supplements are superior to conventional supplements and what their possible role in the treatment of patients with B12 deficiency is.
The Importance of Vitamin B12 in Human Health
Vitamin B12 is synthesized only by certain bacteria and archaea, but not by plants. The synthesized vitamin B12 is transferred and accumulates in animal tissues, which can occur in certain plant and mushroom species through microbial interaction.
The usual dietary sources of vitamin B12 are animal-source based foods, including meat, milk, eggs, fish, and shellfish, although a few plant-based foods such as certain types of dried lavers (nori) and mushrooms contain substantial and considerable amounts of vitamin B12, respectively.
Vitamin B12 is required for the proper function and development of the brain, nerves, blood cells, and many other parts of the body.
Vitamin B12 deficiency is a common but under-recognized condition which can present with non-specific clinical features and in severe cases with neurological or hematological abnormalities.
Pernicious anemia, also known as vitamin B12 deficiency, is defined by two factors that are detected during blood tests and it occurs, when a person lacks the intrinsic agent and cannot absorb B12. It is the most common cause of malignant anemia and is defined as an autoimmune reaction that attacks and destroys those cells of the stomach that produce the endogenous factor.
Immature, abnormally large red blood cells are fragile megaloblastic erythrocytes which are very inefficient for oxygen transport and white blood cells that are made up of abnormal nuclei.
Early symptoms of vitamin B12 deficiency include:
⇝ weakness & fatigue
⇝ pale skin & paleness
⇝ constipation or diarrhea
⇝ loss of appetite & weight loss
⇝ indigestion
⇝ fragile nails
⇝ dark circles
⇝ changes in behavior
⇝ rapid heartbeat
⇝ a disorder of reflexes
⇝ muscle weakness
⇝ neuropathic pain
⇝ loss of vision
⇝ reduction of cognitive capacity
⇝ changes in memory
⇝ depression and confusion
Further studies may also be useful to evaluate whether liposomal B12 supplements are superior to conventional supplements and what their possible role in the treatment of patients with B12 deficiency is.
The absorption of vitamin B12 is a complex process, subject to various problems, in many places. Any deficiencies of:
➤ pepsin,
➤ hydrochloric acid,
➤ R-protein,
➤ pancreatic enzymes,
➤ endogenous factor,
➤ calcium receptors, and cells
can all lead to B12 deficiency through blocked absorption!
Vitamin B12 contributes:
✓ to the normal function of metabolic processes aimed towards energy production, and can reduce fatigue and tiredness symptoms
✓ to the process of cell division
✓ to red blood cells formation
✓ normal homocysteine metabolism
✓ normal psychological function
✓normal functioning of the nervous and immune system
In this first case series study on Liposomal Vitamin B12 supplementation, it was found that this new formulation presents significant effectiveness in a very short period for the patients. Further studies may also be useful to signify the potential role of liposomal supplements vs. conventional food supplements orally administered.
This is a first step in presenting a new generation of Liposomal Vitamin B12 supplementation and their possible role in the treatment of patients with Β12 deficiency, which was found not be relevant to biometric and lifestyle factors.